Abstract

Case Report

Nicotinamide as a treatment option of Age-Related Macular Degeneration

Christine Skerka*, Yuchen Lin and Peter F. Zipfel

Published: 21 September, 2017 | Volume 1 - Issue 1 | Pages: 063-065

Age related macular degeneration is a severe disease of mainly elderly people and leads to central vision loss because of the degeneration of the retinal pigment epithelium [1]. Genetic and environmental factors are responsible for the accumulation of extracellular material and deposit formation near the retinal pigment epithelial (RPE) layer, which leads to loss of photoreceptors and induction of chronic inflammation. The deposits are composed of lipids and proteins including many complement proteins, indicating the involvement of the complement system in the degenerative process and chronic inflammation [2]. So far there is no treatment for the dry form of AMD, except nutritional supplementation with antioxidants and vitamins [3]. Combined with a prolonged lifetime expectation in developed countries, AMD is developing to a social and economic burden. Therefore, there is an urgent need for a treatment of AMD that can delay disease manifestation and progression for several years. 

Read Full Article HTML DOI: 10.29328/journal.jsctt.1001006 Cite this Article Read Full Article PDF

References

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