The complement cascade as a target against SARS-CoV-2-induced pneumonia

Gianluigi Ferretti*

Published: 14 February, 2023 | Volume 7 - Issue 1 | Pages: 001-002

Fox, et al. [1] reported on the relevant cardiopulmonary findings in a series of autopsies of patients deceased from SARS-CoV-2 infection. In particular, regarding the histologic examination of the lungs, they observed bilateral diffuse alveolar damage with a lymphocytic infiltrate, thickened alveolar capillaries, fibrin thrombi within the capillaries and small vessels, and entrapment of neutrophils, without any significant neutrophilic, infiltrate within airways or the interstitium. 

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